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Image Search Results
Journal: Cell Communication and Signaling : CCS
Article Title: Dissociation of the nuclear WWOX/TRAF2 switch renders UV/cold shock-mediated nuclear bubbling cell death at low temperatures
doi: 10.1186/s12964-024-01866-6
Figure Lengend Snippet: Dramatic increases in cell thickness during apoptosis, but not BCD, determined by time-lapse holographic microscopy. A , B COS7 cells were exposed to UV and then cold shock at 4 °C for 12 h. Cell bubbles were observed, as determined by light and holographic microscopy, respectively. The COS7 cell thickness (height) is approximately 4.5 μm, and the bubble thickness less than 2 μm ( n = 10; p < 0.0001 versus time zero controls; Student’s t-test). C Under similar conditions, time-related bubbling is shown at 4 °C in L929S cells. D By contrast, staurosporine-induced apoptosis of L929S cells at 37 °C exhibited condensation and increased whole cell thickness reaching ~ 12 μm. E A summarized graph shows the changes in area, thickness, and volume of COS7 and L929S cells during BCD and apoptosis
Article Snippet: Further, UV/cold shock-treated cells were imaged by
Techniques: Microscopy